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Title   Cisplatin 병합 화학요법에 의한 오심 및 구토에서 Ondansetron 의 효과에 대한 연구 ( Efficacy of Ondansetron is Cisplatin - Induced Nausea and Vomiting )
Publicationinfo   1993 Jan; 025(06): 975-982.
Key_word   Ondansetron
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Abstract   Ondansetron(GR 38032F) is an antiemetic agent with a selective antagonistic action to sero- tonin S3 receptors, devoid of antidopaminergic property. The effects of ondansetron in control of nausea and emesis induced by cisplatin containing chemotherapy regimen were compared to those of formerly used antiemtic agents, MDL (metoclopramide, dexamethasone, lorazepam combination) therapy. Ondansetron was given to the patient, who had vomiting in first and second cycle of chemo- therapy containing cisplatin with MDL therapy. It was administered intravenously l5 min before and 4 hours and 8 hours after cisplatin administration, then given orally every l2 hour up to 24 hours after end of chemotherapy. No other antiemetics were used. Major control(complete and near complete) of emesis was achieved in 2 of 30(6.7%) patients receiving ondansetron and in 4 of 30(l3.3%) patients receiving MLD. For acute emesis, major control was achieved in 24 of 30(80.0%) patients with ondansetron. For delayed emesis, major control was achieved in 3 of 30(10.0%) patients with ondansetron. No severe side reaction was seen in patients receiving ondansetron, while transient elevations in aspartate or alanine aminotransferase level were observed in l0 patients. In conclusion, ondansetron was safe and effective in controlling the acute emesis, comparable to MDL therapy, but was less effective in contralling delayed emesis.
저 자   김금정(Keum Jung Kim),김정백(Jung Beck Kim),김광미(Kwang Mi Kim),박정숙(Jeong Sook Park),박순희(Soon Hee Park),김시영(Si Young Kim),윤휘중(Hwi Joong Yoon),조경삼(Kyung Sam Cho)